Health

Why it is important to learn about Senescence-associated secretory phenotype (SASP) proteins

By Juman Hijab

Reading time: minutes

Original date: July 16, 2023

Updated: April 29, 2026

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Table Of Contents

1

Senescent cells

1.1

How cells reach their end-game

1.2

The Beneficial and Damaging Effects of SASP Proteins

1.2.1

The Role of Exercise in Reducing SASP Proteins

1.3

The bystander effect of SASP proteins

1.3.1

SASP proteins induce a DNA damage response

1.3.2

SASP Proteins have local and systemic effects

1.3.3

SASP proteins create a vicious cycle of a pro-inflammatory state

1.4

Senotherapy: Treatments that control SASP proteins

1.5

1.6

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